What is collagen?
Collagen is a basic building block of our organism – it builds the ‘skeleton’ of cells, tissues and organs of the whole organism, especially the connective tissues (bones, cartilage, tendons, ligaments or skin are mainly made of collagen). It is also responsible for the look and condition of hair, nails or eyeballs. Its deficiency manifest itself not only in our appearance – our skin (darkening, wrinkles, and loss of elasticity) and posture (weakening of joints and muscles) changes but also different health problems is occurring. Amount and quality of collagen mainly determine biological age of humans, which can be easily observed following changes in our skin appearance. It is like that, because lower collagen production comes with age (first symptoms can occur after 30th year of age, more pronounced after circa 40-50th) and during illness. Increasing its synthesis is necessary during physical activity, training and exercises, recovery period and rehabilitation.
Where can we find collagen?
Collagen is produced by specific cells in our body: keratinocytes, fibroblasts and chondrocytes. It is built with the use of amino acids (basic ‘bricks’ of every protein) delivered with food. Many proper amino acids are present in meat, fish and dairy, and majority of them is in structures built with collagen: cartilage and skin. Particularly abundant source of amino acids, that can be easily absorbed, is fish skin – and the best and highly absorbed form – its dehydrated concentrate that is used in Body ReBeauty formula.
Thanks to the presence of Collagen, Body ReBeauty allows for quick complementation of collagen deficiency in organism, cell, tissue and organ renewal is enhanced, strengthening and smoothing of skin occurs, improved functioning of joints and bones. It is especially useful for people after 30s and for younger people on special occasions such as: during the episodes of high physical activity (trainings, summer holidays) or rehabilitation periods, after injuries or illness. It is highly required when one is dieting, especially in case of diet with low amount of animal protein.
Collagen, present in Body ReBeauty supplement, is a worldwide unique tropocollagen hydrate extracted from fish skin, which structure is nearly the same as the human one. Amino acid content of fish proteins is almost the same as human one, and absorption of lyophilizate in near to 100%.
Supplementation with collagen
Need of supplementation of our body with collagen is quite obvious. Engineers and biotechnologists all around the world have the same knowledge about this.
Unfortunately, in practice every dietary supplement produced in the world, under the name ‘collagen’ was proven to be either hydrolysed shredded bovine fibers (in some case even pork ones) or plain gelatine. We do not claim that such products are worthless, but… protein condensation makes these products a very unprofitable purchase. The so called ‘collagen’ present in these products is incomparably less absorbable and contains, in comparison to Body ReBeauty, trace amounts of the most valuable amino acids – primarily hydroxylysine and hydrozyproline. Fish collagen is always tertiary, and this means that it is water-soluble. If it is not the case, we may suspect, that once again marketing term ‘collagen’ has been abused for marketing purposes.
Majority of other dietary supplements, advertising in its content collagen, contain its much worse structures, with debilitated absorption. Body ReBeauty complements our diet with peptides, free amino acids and hydroxy-amino acids. Above all, it is hydroxylysine and hydroxyproline to a small extent provided with food. They are characterised by the ability to effectively stimulate chondrocytes and fibroblasts to produce their own collagen, simultaneously being the best component for its synthesis.
Protein, in the simplest biochemical view is no more than 104 amino acids connected together with peptide bonds. If we estimate, that in protein composition, besides amino acids, are present various elements (mainly carbon, oxygen, nitrogen, hydrogen and sulfur) we can say that protein diversity is almost endless. Average amount of protein necessary to maintain health is about 1,7 g per kg of bodyweight. In human organism, proteins are responsible for almost everything. There are many groups and classifications of proteins. We are interested in functional classification, because this division shows diversity and incredible subtlety of this matter.
- Immunological – i.e. immunoglobulins;
- Building, structural – i.e. keratin, elastin, collagen;
- Regulatory (hormonal regulation, genetic processes regulation)- regulates course of biochemical processes – i.e. growth hormone, insulin, transcriptional factors and other;
- Transport function – hemoglobin, transferrin ;
- Enzymatic catalysis – from carbon dioxide hydration to replication of chromosomes;
- Storing function – ferritin;
- Membrane permeability control – regulation of metabolites concentration in cell;
- Orderly movement – muscle contractions, movements – actin, myosin.
If molecule is built with smaller amount of amino acids than 104 it is called a peptide. We can distinguish two groups of peptides: oligopeptides (several or dozen amino acid residues per molecule) and polypeptides (several dozen amino acid residues per molecule).
Peptides are as important and crucial as proteins, and the fact that there are fewer amino acids and molecule weight is smaller does not mean that these compounds are worse or less valuable. Proteins and peptides are built with amino acids. The problem is absorption and bioavailability of these compounds. It is known that closest aminogram to the human one in nature is found in fish. Composition of their proteins, peptides and amino acids is nearly the same as human and absorption equals 100%. Our product delivers very important groups of components in ideal proportion – these compounds are known as signal proteins. In spite of the fact that, lyophilized collagen is mainly a protein, acidic products obtained from fish skin in temperature lower than 16°C, also contain small signal peptides. They are built with 7-29 amino acids and have regulatory properties in relation to many cells and tissues among others they act as the activators of collagenogenesis process. They can have an impact on regulation of new cells and blood vessels assembly, wound healing, immune and hormonal response. The main advantage of signal peptides is the fact that they stimulate organism to regenerate.
These properties translate into numerous additional effects obtained by the individuals supplementing Body ReBeauty.
Collagen right after it is hydrated, it is broke down to the ‘bricks’ that it was built of – amino acids.
Amino acids ratio in different types of collagen, originating from diverse tissues and species are not the same. For example, the biggest portion of hydroxyproline results in higher resistance of collagen for denaturation in higher temperature, and that is why it is present in bigger amounts in mammals comparing to cold-water fish (which have more alanine, serine, threonine and tyrosine). However basic proportions are the same, independently to the source of collagen. Generally, it is: glycine 33%, proline 14%, alanine 12%, hydroxyproline 10% and a few percent of: lysine, hydroxylysine, threonine, serine, tyrosine, methionine. Other amino acids can be rarely observed, especially in these parts of collagen molecule, that do not have typical triple helix structure, for example at the ends of helix that are called telopeptides.
Each one of amino acids, beside the ability to be used by the organism once again to build its own collagen protein (or other), has its individual properties and can be used to other purposes.
Glycine – the smallest amino acid, often it is a substrate to build other amino acids that are more complexed. It has chelating properties toward metal ions what contributes to the disposal of these metals outside of the organism and results in better absorption of needed elements. It is helpful in synthesis of many important substances in organism such as: growth hormone, elastin, bile acids, hemoglobin, glutathione or DNA and RNA. It also has calming and anti-stress activity and enhances action of other substances of the same characteristics (glutamic acid), and also significantly expands the blood vessels in brain. Thanks to that, it increases concentration, reflexes, memory and also reduces states of permanent fatigue, additionally it promotes healthy sleep. It exhibits anti-inflammatory properties, what is important in case of people suffering from allergies or autoimmune diseases. It elevates hydration and elasticity of skin, accelerates wound healing. Proper excess of glycine in an organism is of big importance in metabolic cycles.
Proline – main property of proline is being the component of structural proteins (for example: collagen, elastin, and also keratin), so it corrects the state of all organs, skin, hair and nails. It exhibits a great ability to absorb water, and when this absorption occurs it disrupts the structure of collagen, the proline is still absorbing water and causes further swelling of the specimen. This property is also important for moisturizing deep layers of dermis. Proline is also the most anabolic amino acid, and what is more it is the most desired amino acid of such properties in the organism. So, it is one of the most important supplemented substances in bodybuilding, and also in regeneration processes and muscle fatigue.
Alanine – Alanine plays a key role in process of nitrogen transportation between muscles and liver and also helps in synthesis of glucose from compounds different than sugars. It has a beneficial effect on energetic processes, especially during physical exercises. Alanine also takes part in blood sugar level regulation, metabolism of organic acids and production of antibodies. It can sooth the effects of mild prostate hypertrophy. It is also a component of pantothenic acid (vitamin of B family), carnosine (diaminoacidic compound, essential for muscle functioning) and valine (amino acid necessary in development of erythrocytes – red blood cells responsible for oxygen transportation – which is what physical fitness depends on). Its slightly modified form has a great effect on reducing fatigue and affects the efficiency and endurance of muscles. With glycine it helps to survive stages of starvation and poisoning.
Hydroxyproline – It is not an amino acid of which the proteins are built – it is created after the protein development, from proline and with the help of vitamin C, lysine and silicon. It is an amino acid superior to collagen and collagen-like proteins. Its presence stimulates the collagen producing cells to elevate collagen production, and even their proliferation. It strongly stabilizes the collagen chain, so the more hydroxyproline present, the collagen becomes harder to damage.
Lysine – It is an amino acid, which is not produced by the human body (exogenous) and it has to be deliver from the outside. Irreplaceable component of enormous majority of proteins, including those life-dependent. It is also essential in the collagen production process (and only as its component), but also hormones and antibodies. It takes part in muscle and bones formation. It stimulates the synthesis of growth hormone. It has a big role in cancer prevention (with antioxidants), and especially (with acetylsalicylic acid) in prevention of metastasis. It soothes the symptoms of viral diseases and slows the expansion of viruses, especially herpes and papilloma. It is a precursor of carnitine (compound essential for muscle work) and strengthens the walls of blood vessels, so it takes part in maintaining the healthy state of cardiovascular system. Its deficiency results in fatigue and agitation, causes anemia, hair loss, interfere in calcium metabolism of the organism (even in optimal vitamin D levels). It is really important in case of people susceptible to osteoporosis. Lysine also affects increasingly mind activity (concentration, memory), as well as physical activity. Lysine and arginine (another protein amino acid) inhibit the absorption of each other in the digestive system, so during increasing the dose of lysine, it is necessary to lower the level of arginine (with some exceptions), and so it won’t block the absorption of lysine. That situation takes place in Body ReBeauty, because collagen does not really consists of arginine.
Hydroxylysine – same as hydroxyproline, it is not inserted into the structure of collagen protein during its assembly, but it’s created by conversion already inserted lysine – it also doesn’t occur in other collagen-like proteins. Similarly as hydroxyproline, it promotes the synthesis of collagen and it is used to cure injuries in sports as well as in their prevention.
Threonine – It is an exogenous amino acid (same as vitamins, it is not produced by human body). Threonine is essential in process of new muscle proteins synthesis. It is necessary for proper functioning of nervous system (depression and other neurological disorders) and immune system (production of antibodies), it promotes healthy functioning of digestive system, acting favourably on stomach’s mucous membranes and liver functioning. It is a factor correcting the skin hydration, especially in its deeper layers, so it affects its softness, firmness and elasticity. It also takes part in maintaining the proper build of enamel.
Serine – one of the amino acids of small build (just after glycine). It takes part in nervous system development – especially of the brain and it contributes to metabolism of fats and DNA and RNA synthesis. It is important for proper functioning of immune system. It is a component of myeloid sheath of nerves (particularly important for people suffering from multiple sclerosis). It soothes the pain and acts as antidepressant, it augments concentration and memory.
Tyrosine – it is an amino acid, which can be produced by the human body, but often this process is not efficient enough, so if it is not delivered in proper amounts the deficiency can be developed. The organism uses tyrosine in very many processes. First of all, it is a substrate used for production of neurotransmitters – substances affecting the brain and the whole nervous system: adrenalin, noradrenalin, norepinephrine and dopamine. Especially the last one is of great importance for our mood and energy, its deficiency is the main cause of depression. Also thyroid hormones (thyroxine and triiodothyronine) steering the metabolism of the whole organism are products of tyrosine metabolism. In result, supplying the organism with tyrosine, through maintaining the proper level of neurotransmitters, it lowers psychological and physical fatigue or other effects of intensive efforts and also augments the functioning of the brain increasing concentration and stress resistance. It also elevates the willingness to act and has a strong antidepressant activity (better than most of the synthetic drugs), and in many cases it helps in curing the Parkinson disease. Additionally, it decreases appetite and through elevating the production of thyroid hormones it greatly increases burning of calories creating energy and lowering body mass. It corrects the functioning of other secretory glands: adrenal and pituitary. Supplementation of thyrosine delivers great results in treatment of addictions, neurological or hormone diseases. Moreover, melanin, skin and hair pigment is also produced from this amino acid – its supplementation can prevent greying and discoloration of hair.
Methionine – it is an exogenous amino acid – the human body does not produce it. It takes part in synthesis of every protein; it plays a role in stabilisation of DNA, helps in conversion of fats into primary component of cell membranes – phospholipids. It is also the main substrate, which is essential in many processes of methylation, what makes its deficiency very dangerous for the organism. Thanks to it, the most important endogenous antioxidant is produced – glutathione. Methionine, itself also exhibits antioxidant properties. It takes part in absorption of zinc and copper from food. It is necessary for biosynthesis of cysteine, karnitine, taurine, lecithin, choline, creatine, adrenalin and many other important compounds. It slows the process of fatty liver development and helps in detoxifying processes. It plays a role in thyroid and other glands regulation. It is also a regulator of nervous and muscle system. It prevents the creation of gallstones and kidney stones, atherosclerosis and heavy metal poisoning.
All in all, Body ReBeauty, after hydration and disassembly into single amino acids – is a source of them for the organism in similar proportions, which are found in collagen, mainly: glycine, proline and alanine. However, regular supplementation of Body ReBeauty also protects, in a great level, from deficiencies of other described amino acids. Delivery of collagen amino acids is essential for healthy functioning and look of the organism, and also the healthy functioning of the mind.